Vitamin C Reverses Skin Aging: Activates Genes For Renewal

Currently, scientists in Japan have discovered that VC helps enlarge the skin by straight turning on genes that regulate skin cell development and growth. Their findings, released online in the Journal of Investigative Dermatology on April 20, 2025, suggest that VC may bring back skin feature by reactivating genes crucial for epidermal revival.

Vitamin C and Epidermal Revival

“We found that VC helps enlarge the skin by urging keratinocyte expansion via DNA demethylation, making it an encouraging treatment for thinning skin, particularly in older grownups,” ends Dr. Ishigami.

As we age, the epidermis– the outermost layer of skin– gradually ends up being thinner and sheds its protective toughness. Concerning 90% of the cells in this layer are keratinocytes, which originate from much deeper layers of the skin and move up, eventually developing the skin’s protective obstacle. To fight aging’s influence on skin, various studies have actually highlighted the advantages of vitamin C (VC), a vitamin well recognized for its duty in skin health and wellness and antioxidant homes.

How Vitamin C Promotes Skin Renewal

These searchings for expose how VC promotes skin renewal by causing genetic pathways involved in development and repair. This suggests that VC might be particularly practical for older adults or those with harmed or thinning skin, enhancing the skin’s all-natural capability to restore and enhance itself.

Japanese researchers have discovered that vitamin C can enlarge skin by activating genes that increase skin cell growth, helping reverse age-related thinning. It works by reactivating DNA through a process that allows cells restore better– possibly a game-changer for aging skin.

Vitamin C Enlarges Skin: Key Findings

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To explore exactly how VC affects skin regeneration, the team used human epidermal equivalents, which are laboratory-grown versions that closely mimic actual human skin. In this model, skin cells are exposed to air on the surface while being nourished from beneath by a fluid vitamins and mineral tool, reproducing the way human skin gets nutrients from underlying capillary while staying exposed to the external atmosphere.

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Regarding 90% of the cells in this layer are keratinocytes, which stem from much deeper layers of the epidermis and move upwards, inevitably forming the skin’s protective barrier. To battle aging’s impact on skin, countless researches have actually stressed the benefits of vitamin C (VC), a vitamin well recognized for its duty in skin health and wellness and antioxidant buildings.

Mechanism of Action: DNA Demethylation

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The scientists further recognized over 10,138 hypomethylated differentially methylated areas in VC-treated skin and observed a 1.6- to 75.2-fold increase in the expression of 12 vital proliferation-related genetics. When a TET enzyme inhibitor was applied, these effects were turned around, validating that VC features with TET-mediated DNA demethylation.

On examining its result, they located that VC-treated skin revealed a thicker epidermal cell layer without considerably affecting the stratum corneum (the outer layer made up of dead cells) on day 7. Samples treated with VC showed boosted cell proliferation, shown by a greater number of Ki-67-positive cells– a healthy protein pen present in the nucleus of actively splitting cells.

VC Influences Skin Structure

Significantly, the study disclosed that VC helps skin cells expand by reactivating genes related to cell expansion. It does so by advertising the elimination of methyl groups from DNA, in a process known as DNA demethylation. When DNA is methylated, methyl groups connect to cytosine bases, which can prevent the DNA from being recorded or read, therefore suppressing gene activity. Conversely, by advertising DNA demethylation, VC promotes genetics expression and aids cells to grow, multiply, and separate.

“VC appears to affect the framework and function of skin, especially by managing the development of skin cells. In this study, we investigated whether it promotes cell expansion and differentiation via epigenetic changes,” clarifies Dr. Ishigami, while talking about this research study.

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On examining its impact, they located that VC-treated skin showed a thicker epidermal cell layer without dramatically affecting the stratum corneum (the outer layer composed of dead cells) on day seven. Notably, the research study exposed that VC assists skin cells expand by reactivating genes associated with cell expansion.