Low-Dose THC & Anti-Inflammatory: New Hope for Alzheimer’s Memory

New research suggests low-dose THC combined with an anti-inflammatory medicine could protect memory and reduce mental retardation in Alzheimer's, a disease affecting millions and previously resistant to COX-2 preventions, offering a faster potential therapy.

In the past, researchers attempted providing Alzheimer’s people COX-2 preventions, a course of medicines that obstruct the enzyme to reduce swelling. The therapy failed to enhance their cognition, and it was linked to dangerous cardio side effects.

THC and Anti-Inflammatory Potential

A new research suggests reduced doses of THC, the major psychoactive active ingredient in cannabis, might shield memory and decrease mental retardation linked to Alzheimer’s when integrated with an anti-inflammatory medicine.

“If you create a brand-new substance, it can take 10 to 20 years to get to clients,” Dr. Chu Chen, a teacher in the Department of Cellular and Integrative Physiology at UT Health And Wellness San Antonio, said in a news release.

The Growing Alzheimer’s Epidemic

That’s possibly significant– especially considering that more than 7 million Americans currently have Alzheimer’s, which number is anticipated to almost dual by 2060 unless scientists locate new methods to prevent or heal it.

After all, the disease isn’t just amnesia. Gradually, it slowly gnaws at a person’s character, believing and reasoning skills, ultimately making it challenging for them to execute even the simplest jobs.

And the threat is high: More than 1 in 9 individuals ages 65 and up has Alzheimer’s, and a 2025 study discovered that about 42% of Americans over 55 will certainly establish mental deterioration later in life, with Alzheimer’s being the most common type.

Understanding Natural Cannabinoids

Endocannabinoids, cannabinoids generated normally in the brain, act upon the same receptors as THC however usually have the contrary result. One essential endocannabinoid, 2-AG, decreases COX-2 task and cuts neuroinflammation.