Mucosal COVID-19 boosters outperform mRNA shots in preventing upper airway infections
In the present study, the researchers used Macaca mulatta or rhesus macaques to investigate the protective immune responses elicited by a mucosal bivalent adenoviral vector vaccine containing stabilized spike protein from the ancestral Wuhan strain and the Omicron BA.5 variant of SARS-CoV-2.