Northwestern University researchers found that DNA strand separation needs more mechanical pressure than previously thought due to the crowded cellular environment and protein interactions. DNA+Cell+Mechanics
"We've made our protein mislocalization database available as a comprehensive resource that can be used by other researchers to expand our collective knowledge on the effects of genetic variation on human disease," said Anne Carpenter, co-principal investigator on the study and senior director of the Imaging Platform at the Broad Institute.
"We see certain individuals, especially children, with very high levels of immunoglobulins, which the body uses to battle disease, and C-reactive protein, which people produce when they are under stress," said Jelmer Eerkens, an anthropology professor at University of California, Davis and one of the corresponding authors on the paper.
